The regular NFL season is back and we are here to provide you with your weekly AFC South Week preview. So let’s take a look around the division at the Week 4 match-ups. We also give you our score predictions and the latest on injuries and betting lines.

Buffalo Bills (2-1) at Houston Texans (2-1)

Kickoff Sunday at Noon CST on CBS

Reliant Stadium Houston, Texas

Only the most rabid of Texans and Bills fans could have thought they would be sitting atop their AFC divisions getting ready for a prime time match-up in Week 4 yet here we are. The Texans were undefeated and riding good play from quarterback Ryan Fitzpatrick until they ran up against a suddenly improved New York Giants team last week. Fitzpatrick threw three picks in that blowout loss. The Bills were also undefeated until they lost to the Chargers 22-10 in Week 3 as well.

Fitzpatrick surely wants to  beat his former team that released him and drafted EJ Manuel as his replacement. Manuel struggled with a knee injury in his rookie season and his effectiveness was limited. He is improved but no doubt both teams will try to run the ball and let their quarterback play game manager. Former Texan Mario Williams is surely looking forward to beasting against his old team.

Vegas has pulled the line likely because awaiting more Arian Foster news. All indications are he will be a game time decision as will punter Shane Lechler. DJ Swearinger is expected to play with a brace. For the Bills, offensive lineman Chris Williams, wide receiver Marquise Goodwin and linebacker Keith Rivers are doubtful and not expected to play. The temperature is expected to reach a high of 89 and partly cloudy skies so the retractable roof will likely be closed.

Texans at Bills

Chart courtesy of NFL.com/gamecenter

Final score prediction:

Bills 21

Texans 24

Tennessee Titans (1-2) at Indianapolis Colts (1-2)

Kickoff Sunday at Noon CST on CBS

Lucas Oil Stadium Indianapolis, Indiana

Will he or won’t he? That seems to be the question Vegas is asking as the Titans travel to Indianapolis to take on their division rival the Colts. After allegedly sustaining a wrist injury in Week 3 against the Bengals, Locker hasn’t practiced at all this week and it seems likely Charlie Whitehurst will play in his stead. Whitehurst is a career backup but It’s possible he can give the Titans offense a boost it surely needs.

The Colts overwhelmingly own this series and the Titans have never won at Lucas Oil Stadium dropping the past six games there. In their previous matchups, the Titans have consistently given up leads and have had no answers for either Peyton Manning or Andrew Luck. Luck has never lost to the Titans.

You can find our full preview here.

comparison

Chart courtesy of NFL.com/gamecenter

Final score prediction:

Titans 13

Colts 27

Jacksonville Jaguars (0-3) at San Diego Chargers (2-1)

Kickoff Sunday at 3:05 CST on CBS

Qualcomm Stadium San Diego, California

The Blake Bortles era has finally arrived for the Jacksonville Jaguars who have yet to notch their first win of the season in what has been looking like a repeat of 2013 when they lost eight in a row. The Chargers are rolling but also lost Danny Woodhead for the year and Ryan Matthews for a few games due to injuries. They also look to be without tight end Ladarius Green (hamstring), rookie cornerback Jason Verrett (hamstring) and rookie linebacker Jeremiah Attaochu (hamstring) as all are questionable for Sunday.

chargers rankings jaguars rankings

The hapless Jaguars are dead last in the league on defense and pretty close to it offensively. Bortles might not be quite be ready for primetime but he is better than what he is replacing in journeyman Chad Henne who has struggled behind a poor offensive line. The Jaguars defense has been putrid, giving up almost 40 points per game as well.

Vegas currently has the Chargers winning by two touchdowns and I might take the Jaguars in this one despite their atrocious start. An anemic offense can stymie a defense and there is cause to believe the Jaguars can put up some points despite injuries to wide receiver Marquise Lee (hamstring), tight end Mickey Shuler (illness), and wide receiver Allen Hurns (ankle). Lee and Shuler are out and the others are expected to play.

Jags at Chargers

Chart courtesy of NFL.com/gamecenter

Final score prediction:

Jaguars 21

Chargers 31

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